Starting a Randomizer/Chaos is the hardest part as the key items needed to progress though the game are shuffled.
This guide offers tips help you get the starter key items which help you get momentum to beat the run.
Starting a Chaos/Randomizer Run
After beating the game once make a new save file and talk to the blue wizard fellow
He will take you to the altar dimension.
Go to the left and interact with these red crystal
He will take you to the randomizer seed room
Input any seed you want and talk to the red crystal to start the challenge
Pre Pickaxe Items Locations
Finding the Pickaxe is the next step and it could be anywhere. These are the possible locations
bush next to lynn’s house
crate next to tess’s shop
bush outside oakley’s shop
bush next to the bridge
a plant pot in the dining room of ashwood’s house
inside the warehouse, to the very back
a cactus across from where crocodile stands upstairs in the casino
chest where pickaxe normally is
Ideally you now have the Pickaxe
Post Pickaxe Locations
Now that you have a pickaxe you have access to more items to find the dredge hand.
Mushroom in forest
Heart Ore by River’s house
Create by Tidal Mine
First chest in Boneyard
Secret room in boneyard (3 chests)
Bush near the island where frost flower is
Inside Pirate Cove chest
Getting Knuckle and Lariat
Now that you have a pickaxe and dredge hand let’s work on getting the Rust Knuckle and Lariat
Get the key to tidal mine from Mariana
Make sure to get the harmonica from Grandpa’s bedside
Enter Tidal Mine and Move the Turtle
Buy the Knuckle and Lariat from Zaegul’s Secret Shop
Go Beat the Game
At this point you should have all the key items you should be able beat all the dungeons as well get all the items in the overworld. Remember that most dungeons have a secret room that will contain a chest or 2.
To Beat Act 1 you need
Drowned Ore
Shaedrite
Miasmic Extract
Broken Sword
To Beat Act 2 you need
Any 2 of the following:
Fury Heart
Frozen Heart
The Shattered Soul
The Splinter
The Sunset Painting
Since items are random you just need to loot items until you get the items you need.
After getting color corrected in Act 2 you go to the lighthouse and beat the game.
Things can get a little silly as you can randomly get late game items that can unlock all sorts of late game dungeons.